NF-kB Decoy kit

NFκB Decoy Nucleic Acid Reagent Kit/Ribbon Type Decoy Nucleic Acid Reagent Kit

 

Product features

NFκB decoy nucleic acid has been attracting close attention as an element for development of drugs for the treatment of inflammatory diseases such as atopic dermatitis and rheumatoid arthritis.

Conventional treatment of many inflammatory diseases such as rheumatoid arthritis and allergic dermatitis primarily used drug therapy designed to suppress pain, but radical treatment of these diseases has not been possible.  The efficacy has been particularly poor in severely sick patients.

Treatment with NFκB decoy nucleic acid is aimed at suppressing the activity of NFκB which stimulates the formation of proteins (cytokines) responsible for inflammation.  This approach of treatment can erase the underlying cause of itching sensation and pain.

Decoy nucleic acid is capable of inhibiting the transcription factors playing an important role in gene activation and is thus useful in elucidation of life phenomena and development of materials for medical use.  However, conventional decoy nucleic acid had disadvantages such as likelihood for decomposition in serum, difficulty for uptake by cells, and so on.  For these reasons, we have modified the structure of decoy nucleic acid from the conventional double-strand form into ribbon type form.  This resulted in improved resistance to nuclease, enabling development of decoy nucleic acid stable also in serum.

The NFκB decoy oligo produced by GeneDesign Inc. is provided to researchers in the form of reagent kit for use in various research on decoy.

[This product was developed under the research program “Technological Development of New Ribbon Type Decoy Nucleic Acid” within the framework of the Ministry of Economy, Industry and Trade (METI) Regional Revival Consortium Research and Development Project.]

 Price ( Shipping fee is necessary other than product price .)
Product Description Cat.No. Price
NFκB Decoy Oligonucleotides Kit Double-strand
Natural type
DN-15101 ¥45,000
NFκB Decoy Oligonucleotides Kit Double-strand
Total S-form
DN-15102 ¥55,000
RIBBON NFκB Decoy Oligonucleotides Kit Ribbon type
Natural type
DN-25101 ¥65,000
RIBBON NFκB Decoy Partial S Oligonucleotides Kit Ribbon type
Partial S-form
DN-25102 ¥75,000

*All products undergo HPLC purification.

**Stock may be in short depending on situations of orders.

Contact us about the delivery schedule.

*Contact us about the price for FAM modification and other modifications.

*Products tailored to client’s requests may be provided.  Contact us for details.

Outline

GeneDesign, Inc. is capable of synthesizing siRNA, aptamars, antisenses, etc. of in vivo grade applicable to preclinical studies, etc.  We can supply oligo-DNA/RNA/BNA in a form optimal for in vivo studies through lyophilizing under sterilized environments after filtration.  All products are checked as to endotoxins before delivery.  We can estimate the cost tailored to your demands (scale of synthesis, grade of purification, necessity of modifications, etc.).

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